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Jacques Haiech Selected Research

Bisacodyl (Bicol)

6/2018WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.
6/2017Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling.
1/2015Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.

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Jacques Haiech Research Topics

Disease

13Neoplasms (Cancer)
06/2018 - 08/2008
8Glioblastoma (Glioblastoma Multiforme)
06/2018 - 06/2009
3Inflammation (Inflammations)
10/2015 - 08/2008
2Eosinophilia
01/2018 - 01/2012
2Brain Injuries (Brain Injury)
11/2010 - 10/2003
2Neurodegenerative Diseases (Neurodegenerative Disease)
11/2010 - 01/2002
1Carcinogenesis
01/2018
1Hypertension (High Blood Pressure)
01/2016
1Pneumonia (Pneumonitis)
10/2015
1Glioma (Gliomas)
01/2015
1Brain Neoplasms (Brain Tumor)
01/2015
1Asthma (Bronchial Asthma)
01/2012
1Neglected Diseases
11/2010
1Autoimmune Diseases (Autoimmune Disease)
04/2010
1Tics (Tic)
02/2010
1Friedreich Ataxia (Friedreich's Ataxia)
08/2009
1Inborn Genetic Diseases (Disease, Hereditary)
08/2009
1Ataxia (Dyssynergia)
08/2009
1Acquired Immunodeficiency Syndrome (AIDS)
07/2009
1Rare Diseases (Rare Disease)
08/2008
1WHIM syndrome
08/2008
1Agammaglobulinemia (Hypogammaglobulinemia)
08/2008
1Communicable Diseases (Infectious Diseases)
08/2008
1Infections
08/2008
1Neoplasm Metastasis (Metastasis)
08/2008
1Warts (Wart)
08/2008
1Ischemia
10/2003
1Hypoxia (Hypoxemia)
10/2003
1Lung Injury
05/2003
1Acute Lung Injury
05/2003
1Ventilator-Induced Lung Injury
05/2003
1Sepsis (Septicemia)
05/2003
1Neuroinflammatory Diseases
01/2003
1Alzheimer Disease (Alzheimer's Disease)
01/2003
1Astrocytoma (Pilocytic Astrocytoma)
07/2002

Drug/Important Bio-Agent (IBA)

7Pharmaceutical PreparationsIBA
01/2016 - 01/2003
3Phosphotransferases (Kinase)IBA
06/2018 - 07/2002
3Bisacodyl (Bicol)FDA Link
06/2018 - 01/2015
2CalciumIBA
01/2018 - 01/2015
2Cytotoxins (Cytolysins)IBA
06/2017 - 01/2015
2ChemokinesIBA
10/2015 - 04/2010
2CytokinesIBA
04/2010 - 01/2002
2Proteins (Proteins, Gene)FDA Link
04/2010 - 08/2009
2Coloring Agents (Dyes)IBA
02/2010 - 06/2009
2EnzymesIBA
05/2003 - 01/2003
1Transcription Factors (Transcription Factor)IBA
01/2018
1ChromatinIBA
01/2018
1histone H3 trimethyl Lys4IBA
01/2018
1Antihypertensive Agents (Antihypertensives)IBA
01/2016
1Prazosin (Minipress)FDA LinkGeneric
01/2016
1Adrenergic Receptors (Adrenergic Receptor)IBA
01/2016
1LaxativesIBA
01/2015
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2014
1ProdrugsIBA
01/2012
1Sulfates (Sulfates, Inorganic)IBA
01/2012
1BuffersIBA
01/2012
1Phosphates (Orthophosphate)IBA
01/2012
1Biological ProductsIBA
11/2010
1Praziquantel (Biltricide)FDA Link
11/2010
1LigandsIBA
04/2010
1Temozolomide (Temodar)FDA LinkGeneric
02/2010
1Lewis X AntigenIBA
02/2010
1SulfurIBA
08/2009
1IronIBA
08/2009
1Mitochondrial Proteins (Mitochondrial Protein)IBA
08/2009
1FrataxinIBA
08/2009
1Nucleic AcidsIBA
07/2009
1Nucleocapsid ProteinsIBA
07/2009
1N- (4- aminobutyl)- 5- chloro- 2- naphthalenesulfonamide (W13)IBA
06/2009
1indo-1IBA
06/2009
1W 12IBA
06/2009
1AequorinIBA
06/2009
1bifonazoleIBA
06/2009
1calmidazoliumIBA
06/2009
1W 7 (W7)IBA
06/2009
1CXCR4 Receptors (CXCR4 Receptor)IBA
08/2008
1Chemokine CXCL12IBA
08/2008
1Apoptosis Regulatory ProteinsIBA
10/2003
1aminopyridazineIBA
10/2003
1Protein Isoforms (Isoforms)IBA
05/2003
1Protein Kinases (Protein Kinase)IBA
05/2003
1Protein Kinase InhibitorsIBA
01/2003
1Amyloid beta-PeptidesIBA
01/2003

Therapy/Procedure

9Therapeutics
01/2018 - 05/2003
2Drug Therapy (Chemotherapy)
01/2018 - 11/2010
1Oral Administration
01/2018
1Radiotherapy
01/2014
1Aftercare (After-Treatment)
01/2014
1Investigational Therapies (Experimental Therapy)
02/2010
1Artificial Respiration (Mechanical Ventilation)
05/2003